Pulmonary nodules do not necessarily cause chest tightness, and there is no direct relationship between pulmonary nodules and chest tightness, which needs to be determined on a case-by-case basis. Pulmonary nodules are round-like or irregular shaped lesions ≤3 cm in diameter in the lung, which can be manifested by imaging as increased density shadows, either single or multiple, with clear or unclear borders. The clinical manifestations of pulmonary nodules are closely related to the location of the nodule, the size of the nodule, whether it is compressed, invades adjacent organs, and whether it is a malignant metastasis. Most pulmonary nodules are located inside the lung, away from the pleura and bronchi, so most nodules are found during physical examination or unintentionally. Because pulmonary nodules are up to 3 cm in diameter, they can cause chest tightness and shortness of breath symptoms unless they grow in a special location, such as in the large airways or when they block the airways and cause narrowing by compression, so most pulmonary nodules do not cause shortness of breath symptoms in patients. In addition, some patients with pulmonary nodules do have shortness of breath, but the nodules do not affect the airways, and the patient’s lung function and heart function need to be evaluated. Patients with a long history of chronic bradyarrhea, emphysema, relatively poor cardiopulmonary function reserve, and relatively low basal lung function indexes may have shortness of breath symptoms even if they are not combined with pulmonary nodules. Some patients have airway hyperreactivity due to allergies and other reasons, resulting in shortness of breath, which requires the application of bronchodilators to relieve.