Recently, a patient complained of no hunger and loss of weight for more than 7 years and asked what was wrong and what to look for. The patient’s lack of hunger and low volume of meals are medically known as “epigastric fullness and poor appetite”, and the apparent wasting may be due to reduced food intake and indigestion, with no indication of gastrointestinal absorption dysfunction. According to the information provided so far, the patient may be suffering from functional dyspepsia (dysmotility type). The etiology and pathogenesis of functional dyspepsia are still not fully understood, and it is currently believed that it is mainly related to gastric motility disorders, abnormal visceral sensation and mental or stress factors, among which motility disorders are the main etiology and pathogenesis of functional dyspepsia. The common manifestations of functional dyspepsia (dysmotility type) are: long-term persistent or recurrent epigastric fullness, early satiety, belching, poor appetite, with or without epigastric discomfort or vague pain. Some patients also have insomnia, anxiety, depression, headache, and difficulty concentrating. Chronic poor appetite may cause some degree of nutritional anemia and weight loss. The diagnosis of functional dyspepsia is an exclusionary diagnostic criterion: 1, the above symptoms exist for at least 6 months; 2, gastroscopy, no significant gastric erosion or mucosal atrophy, ulcers of the stomach and duodenum, incomplete pyloric obstruction, gastric cancer or gastric mucosa-associated lymph-like tissue lymphoma; 3, blood tests, abdominal ultrasound examination without liver, gallbladder, pancreas, kidney disease; 4, no diabetes mellitus, connective tissue disease No diabetes mellitus, connective tissue disease and psychiatric disorders; 5. No history of abdominal surgery. In view of the patient’s condition, attention should also be paid to exclude the possibility of the following diseases: chronic atrophic gastritis, anorexia nervosa, diabetic gastroparesis, abnormal gastrointestinal function due to abnormal thyroid function, chronic hepatitis, abnormal gastrointestinal function due to drugs (such as calcium channel blockers like Loxodren, Boydin, drugs for the treatment of diabetes, most antibiotics, long-term application of atropine drugs), etc. . Although the patient’s chronic low food intake can explain the wasting, it is necessary to perform exclusion of gastrointestinal malignancy when the patient has wasting as an early warning symptom of gastrointestinal malignancy. Normal people can defecate 1-3 times a day or 1-3 times a day, and the main nature and character of the stool is normal. What should the patient do in this case? The wise choice is to go to the outpatient or inpatient hospital for the following tests: routine blood tests, routine stool, occult blood and muscle fiber, fat drop test, liver, kidney, thyroid function and fasting and postprandial blood sugar tests, abdominal ultrasound, gastroscopy (when doing gastroscopy, you can observe the peristalsis of the stomach, the amount of gastric juice, whether there are ulcers or tumors, and if necessary, you can determine the pH value of gastric juice or take a biopsy for tissue (for pathological diagnosis, etc.). If the above tests are normal, the diagnosis of functional dyspepsia is supported. If any abnormality is found, it is an organic disease with gastric motility disorder, and then treatment should be carried out for the cause. How should functional dyspepsia be treated? Patients should avoid eating spicy and stimulating foods, durian, mango and chocolate, etc., quit smoking and drinking, eat less frequent meals, less high-fat diet, and participate in more physical activities. It can be assisted by slowly massaging the abdomen with the hand in a clockwise direction for 20-30 minutes each time, several times a day. The first generation of gastric motivation drugs: Gastrofluan, because of more adverse drug reactions, oral tablets are rarely used, but intramuscular injections are still used. The second generation of gastric motility drugs: domperidone (i.e. morpholine), is a non-prescription drugs, general pharmacies have for sale, each 10mg, 3 times a day, half an hour before meals, generally take 2-4 weeks; the third generation of gastric motility drugs: these drugs have the whole gastrointestinal tract to promote the role of power, generally should be applied under the guidance of a doctor, such as mosapride preparation, each 5mg, 3 times a day, half an hour before meals The effect is better. If accompanied by abdominal pain, H2 receptor antagonists, such as famotidine, 20 mg each time, 1-2 times a day, can be applied appropriately. If there are obvious manifestations of anxiety and depression, some anti-anxiety and depression drugs, such as Gaglodin and Dextran, can be used as an adjunct, but such drugs must be taken under the guidance of a doctor. However, what if there are no conditions for the above mentioned tests? You can apply the above treatment for 1-2 weeks, if the effect is good, you can continue the treatment for a period of time, if the effect is poor, or find a way to check, otherwise the course of the disease is delayed, the money to spend more later. Some people think that “from time to time to make the stomach and intestines feel hungry, conducive to gastrointestinal function health care”, is this reasonable? There is some truth to this. The normal human gastrointestinal tract activities by the brain and the gastrointestinal tract nerve plexus dual command, under constant training after birth, with conditional reflexes and unconditional firing activities, generally divided into digestive (when eating) activities and inter-digestive (non-eating) activities, such as people constantly eating or food can not be emptied, the gastrointestinal tract activities will continue to carry out the activities of the digestive period, just like a person is constantly running The consequences can be imagined in the long run. However, if you go for a long time to deliberately create a sense of hunger, but also not conducive to health. People will have normal gastrointestinal function and a healthy life as long as they often maintain a good lifestyle, work style and an optimistic outlook on life, moderate physical activity, a balanced diet, eat at the right time and in the right amount, prevent overeating and quit smoking and drinking.