Long-term constipation will lead to the accumulation of feces in the body for a long time, which over time will lead to the inability to excrete some toxins from the intestinal tract and affect the composition of the intestinal flora, which may eventually increase the risk of cancer development. Prolonged constipation may be related to cancer. Some organic intestinal lesions, such as tumor occupancy, can lead to long-term constipation in patients. Of course, in addition to stool, patients may experience changes in stool habits and shape, a condition in which medication is not effective and can recur. There are many normal flora in the intestine itself, which can break down food residues, but of course, carcinogenic substances can be produced under abnormal conditions. Long-term constipation causes harmful substances to be discharged ineffectively, and prolonged accumulation in the body will directly stimulate the intestinal mucosa, which may induce tumor production. Epidemiological studies have shown that constipation is the culprit of breast cancer, and constipated patients have more atypical hyperplasia of the breast and ductal epithelium. Some data show that about 10% of patients with severe constipation have colon cancer. In summary, long-term constipation may not only induce cancer, but also be related to many other systemic diseases. Therefore, once constipation occurs, it should be treated in time, and attention should also be paid to the regulation of daily diet.