For oral inflammation, the use of broad-spectrum β-lactam anti-inflammatory drugs, as well as nitroimidazole anti-inflammatory drugs, the effect is relatively good. Most of the β-lactam anti-inflammatory drugs are broad-spectrum antibiotics, common amoxicillin and a variety of cephalosporin antibiotics, are β-lactam broad-spectrum antibiotics, and nitroimidazole antibiotics are commonly used for oral anaerobic bacterial infections, common drugs are metronidazole, ornidazole, tinidazole and so on. These two drugs can be considered in combination to have a better therapeutic effect on the inflammation of the mouth. However, it must be noted that for oral inflammation, the best anti-inflammatory treatment is to find the bacteria that cause inflammation, which can be found by means of bacterial culture combined with drug sensitivity test, and then according to the drug sensitivity results, the application of anti-inflammatory drugs is the best way to apply anti-inflammatory drugs in clinical practice. The method of applying broad-spectrum cephalosporins and nitroimidazoles as anti-inflammatory drugs is empirical.