Hepatitis B can be blocked in pregnant mothers by administering Hepatitis B immunoglobulin during the second trimester of pregnancy and Hepatitis B vaccine and Hepatitis B immunoglobulin to the newborn after delivery. Hepatitis B interruption in pregnant women refers to measures taken during pregnancy and postpartum to interrupt mother-to-child transmission of the hepatitis B virus. The main measure is to inject Hepatitis B immunoglobulin once in the second trimester, i.e. in the 7th, 8th and 9th month of pregnancy, to suppress the Hepatitis B virus in the body and block its intrauterine transmission. After the birth of the newborn, try to get the hepatitis B immunoglobulin and the first dose of hepatitis B vaccine within 2 hours, no later than 24 hours, and then complete the hepatitis B vaccination program at 1 month and 6 months of life. The success rate is higher when the blockade is completed in a standardized manner as prescribed by the doctor, so it is important for pregnant mothers with hepatitis B to take it seriously to reduce the risk of transmitting hepatitis B to their children.