Vaccination during the incubation period of hepatitis B will not produce antibodies. Hepatitis B incubation period refers to the period from the invasion of hepatitis B virus into the body to the appearance of clinical symptoms. Although patients with hepatitis B incubation period do not have obvious clinical symptoms, the virus has already begun to replicate at this time, and the vaccine will not have the effect of eliminating the virus. The incubation period of hepatitis B virus is about six weeks to six months, after which it will induce hepatitis, liver fibrosis, cirrhosis, liver cancer and so on. It threatens the human life safety issues. If patients find themselves in the incubation period of hepatitis B, they need to use drugs carefully to avoid the liver producing some toxic substances during metabolism. At the same time to the hospital for standardized treatment.