The later stages of life for patients with leukemia can be quite painful. Because patients are often poorly treated, refractory or relapsed in the later stages, hemoglobin and platelets are reduced. Decreased hemoglobin may cause symptoms of anemia, such as dizziness, weakness, palpitations, and tinnitus. Thrombocytopenia may result in bleeding gums, nasal bleeding more than once, and may even result in gastrointestinal bleeding, such as blood in the stool and vomiting; bleeding from the respiratory tract, such as hemoptysis, blood in the sputum, or even blood in the urine or intracranial bleeding, which are all very dangerous. In addition, patients who have undergone long-term chemotherapy and poor treatment will often have poor diet and will lose weight. Patients will also have abnormal coagulation function, called DIC, in the advanced stage of tumor, and often all organs of the body will fail or bleed. Patients have abnormal leukocyte function, which leads to white blood cells not being able to fight infection properly, therefore, hard-to-treat infections such as sinusitis, mouth ulcers, and even lung infections may occur, and these conditions may eventually lead to death.