IgA nephropathy is a diagnostic immunopathology name for a group of glomerulonephritis without systemic disease, with IgA-based granular deposits in the glomerular thylakoid region on immunopathological examination of renal biopsy, and clinically manifested mainly by hematuria, which is one of the most common primary glomerular diseases leading to end-stage renal disease with wide distribution and high incidence worldwide. The disease is more prevalent in young people, with a higher incidence in men than in women, and the incidence ratio of men to women in China is 3:1. The disease accounts for about 20%-40% of primary glomerular diseases in the Asia-Pacific region, 10%-30% in the European region, and 26%-34% in China. there is no cure for IgA nephropathy, and it is still at the stage of symptom relief and empirical treatment. The development of treatment principles and treatment plan is mainly based on clinical manifestations and pathological changes. First, general treatment 1, pay attention to keep warm, cold should be treated in time. 2.Avoid strenuous exercise. 3.Control blood pressure, ACEI preparations and diuretics are preferred. 4.Diet therapy, avoid excessive sodium intake and excessive protein intake, ensure adequate caloric supply. 2. Prevention and reduction of antigenic stimulation 1. Anti-infection: prevention and timely treatment of infection with penicillin and vincristine may be helpful for some patients with recurrent granulomatous hematuria as the main manifestation and reversible acute renal failure. 2.Tonsillectomy: IgA nephropathy with sarcoid hematuria as the main manifestation is closely related to upper respiratory tract infection and tonsillitis, the attack of tonsillitis can induce hematuria, tonsillectomy can obviously reduce or eliminate the attack of sarcoid hematuria, reduce proteinuria and lower the serum total IgA level. 3. Reduce the intake of antigenic foods: In addition to bacteria and viruses, certain food components such as gluten, bran and bovine serum proteins can also act as antigens and bind to IgA. Adjustment of abnormal immune response 1, glucocorticoids: including prednisone and methylprednisolone, etc. 2. Immunosuppressants: including cyclophosphamide and cyclosporine A, etc. Clear circulating immune complexes: plasma replacement can rapidly clear IgA immune complexes, mainly used for patients with acute progressive IgA nephropathy. V. Reduce glomerular pathological damage and slow down its progress 1. anticoagulation, antiplatelet aggregation and fibrinolytic drugs: In addition to IgA deposition in the thylakoid area, patients with IgA nephropathy are often combined with C3, IgM and IgG deposition, and some of them also have fibrinogen deposition, so most of them are treated with anticoagulation, antiplatelet aggregation and fibrinolytic drugs, such as heparin, urokinase, warfarin and dipyridamole, etc. 2, angiotensin-converting enzyme inhibitors (ACEI): the role of this class of drugs is mainly to expand the small glomerular arteries, reduce glomerular hyperperfusion and permeability of the basement membrane, inhibit thylakoid proliferation, to reduce the urinary protein of patients with IgA nephropathy, reduce blood pressure, and protect renal function has a more positive effect. At present, the commonly used ones are: Lortin, Mono, suppressing Pinoxol, etc. 3, fish oil: fish oil is rich in polyunsaturated fatty acids, which can reduce glomerular damage and glomerulosclerosis.