Atrophic gastritis of the gastric sinus may become cancerous, the details vary from person to person. Atrophic gastritis of the gastric sinus is a precancerous lesion of gastric cancer, which may progress to gastric cancer if not treated in time, but not all people will progress to gastric cancer, which is related to individual’s physique. Helicobacter pylori infection is an important cause of chronic gastritis, so patients with atrophic gastritis of the gastric sinus should first consider whether there is Helicobacter pylori infection, the breath test is the main way to detect the bacteria, and those who have a positive test result should be given quadruple drug therapy. The specific drug combination is a proton pump inhibitor (esomeprazole) + two antibiotics (amoxicillin, furazolidone) + bismuth (colloidal bismuth pectin), and the recommended duration of treatment is 10 to 14 days. In addition to eradication of H. pylori, people with atrophic gastritis of the gastric sinus can also be treated with herbal medicines as prescribed by the doctor, with regular review of gastroscopy and follow-up to prevent gastric cancer. The above medications should be used in accordance with the doctor’s prescription, do not use drugs without authorization, to avoid adverse reactions brought about by the drugs.