Neurosis is caused by patients being under prolonged tension and stress, with easy mental excitement and brain fatigue, often accompanied by emotional worries, irritability, sleep disorders, and muscle tension pain, which cannot be attributed to brain and somatic diseases and other psychiatric disorders. Drugs commonly used in the treatment of neurasthenia include anxiolytics, antidepressants, sedative-hypnotics and nerve blockers. Anti-anxiety drugs are preferred to benzodiazepines, such as diazepam and eszopiclone, which can help patients improve symptoms such as anxiety, tension and sleep disorders. Antidepressants are based on selective 5hydroxytryptamine reuptake inhibitors, such as fluoxetine, sertraline, paroxetine, etc. Sedative-hypnotic drugs can significantly improve the patient’s sleep disorder, commonly used are triazolam, eszopiclone, clonazepam, etc. Such drugs have dependence and should not be used for a long time. Nerve blocking agents can inhibit the symptoms of palpitations, tremors and excessive sweating that appear in patients with sympathetic hyperactivity, commonly used are propranolol, Dextran and other drugs. In addition, some Chinese medicinal preparations, such as Guei Shen Wan, Sour Date Soup, Tian Ma and Hooked Vine Drink, are also effective for patients with neurasthenia, and patients can choose to apply them under the guidance of herbalists. It should be noted that neurasthenia should be treated with a combination of medication, psychotherapy and physical therapy under the guidance of a professional neurologist in order to achieve the best treatment effect.