Drinking alcohol the day before the Hepatitis B vaccine can have certain effects, which may cause allergic reactions, lowered immunity, and so on. As both alcohol and hepatitis B vaccine are metabolized in the liver, and drinking alcohol the day before hepatitis B vaccination, the alcohol has not been metabolized, so the injection will increase the burden on the liver, thus affecting the effect of hepatitis B vaccine, in addition, alcohol can cause allergic reactions, easy to be confused with the adverse reactions of the vaccine, not conducive to differential diagnosis. If you drink alcohol the day before the hepatitis B vaccine, it will lower your body’s immunity, thus affecting the antibodies of the hepatitis B vaccine to the body’s immune system. In addition to not consuming alcohol, it is recommended that the vaccinated person avoid staying up late, smoking, or eating too spicy and stimulating food a few days before the hepatitis B vaccine. It is best not to drink alcohol the day before the hepatitis B vaccination, and it is also not recommended to eat some spicy, stimulating and greasy food.