Antigen testing usually cannot replace nucleic acid testing, it can only be used as a supplement to nucleic acid testing, nucleic acid testing is still the “gold standard” for detecting viruses, especially for new coronaviruses, the combination of the two can help improve screening efficiency and help more people get screening results in a shorter period of time. 1, antigen testing 1, advantages: compared with nucleic acid testing, antigen testing has the advantages of fast results, easy to check, can be operated at home; 2, disadvantages: the accuracy rate is low compared with nucleic acid testing, about 80%. Second, the nucleic acid test 1, advantages: high accuracy, basically up to 95% or even higher, the possibility of error is small; 2, disadvantages: slow results, the operation of the trouble, and can not operate on their own, you need to go to the specified test site within a fixed period of time to check. Therefore, for these two different means of detection, it is usually recommended to use a combination to avoid their own shortcomings and complement each other’s strengths. It is conducive to more rapid screening of suspicious persons, which is important for the health of the tested person as well as for epidemic prevention and control. It is also important to note that antigen testing is not only not a substitute for nucleic acid testing, but also cannot be used as a basis for confirming a diagnosis. In other words, if the nucleic acid test result is positive, then the case should be treated as a confirmed case regardless of the antigen test result; if the nucleic acid test result is negative but the antigen test result is positive, then it is also necessary to take isolation measures according to the new coronavirus infection, close observation and continue the nucleic acid test.