Patients with cardiovascular disease tend to pay attention only to their heart rate, blood pressure and lipid profile, and rarely pay attention to the blood uric acid situation. However, blood uric acid is also very harmful to the cardiovascular system, and is often the main factor affecting other indicators that are not well controlled. When it comes to hyperuricemia, the first thing that comes to mind is gout. Yes, the most direct consequence of high uric acid is gout. When it comes to gout, patients will have this experience: it comes and goes like the wind, and the pain is killing them. The symptoms are: the big toe of the foot, the back of the foot, the heel and other places appear obvious redness, swelling, heat and pain performance. The main reason for this is the sudden rise in blood uric acid in a short period of time, causing an acute attack of gout. Hyperuricemia is a prelude to gout. However, since the majority of hyperuricemia do not have gout attacks throughout their lives, and only 5-12% develop gout, many people with hyperuricemia are “fooled” by the condition because they have not experienced the phenomenon of “pain that kills” and do not know that they have hyperuricemia. Therefore, many people with hyperuricemia are not aware that they have hyperuricemia because they have not experienced “pain” and are “fooled” by the condition. Or, even if they know they have hyperuricemia, they may ignore it because they don’t have gout. However, the dangers of hyperuricemia go far beyond gout attacks. Over the past 20 years, several large prospective clinical studies have confirmed that asymptomatic hyperuricemia is a risk factor for cardiovascular disease and that blood uric acid levels are closely associated with cardiovascular mortality. Recently, studies in Taiwan have also found that blood uric acid levels are an independent risk factor for cardiovascular mortality in the general, low-risk and high-risk population in Taiwan. Blood uric acid is also closely related to hypertension. In 1879, Mohamed first proposed that blood uric acid was involved in the development of hypertension; in 1889, Haig proposed that a low purine diet could be used as a means of preventing hypertension: after 1990, several cardiovascular epidemiological studies confirmed that blood uric acid was an independent risk factor for the development of hypertension, and every increase in blood uric acid level For every 59.5 μmol/L increase in blood uric acid level, the relative risk of hypertension increases by 25%. Other studies have shown that about 30% of uncomplicated essential hypertension is associated with hyperuricemia; 25% of patients with untreated hypertension have hyperuricemia; 40% to 50% of patients treated with diuretics have hyperuricemia; and 75% of patients with malignant hypertension have hyperuricemia. Several studies have shown that hyperuricemia and hypertension are causal and mutually reinforcing. Elevated blood uric acid levels also increase the incidence of stroke and mortality. High uric acid is the fourth highest after hypertension, hyperglycemia and hyperlipidemia, which are the “three highs”. The “four highs” take advantage of the opportunity to sneak in and devour our health and even life.