There are two types of drugs for antiviral treatment of hepatitis B: i. Interferon: Advantages: direct antiviral and immunomodulatory effects, better long-term efficacy, relatively fixed course of treatment. The disadvantages: more side effects, to inject the drug, can not be used for severe liver failure and decompensated cirrhosis. The long-acting interferon is more effective, more convenient to inject once a week, but the price is expensive. 2, domestic interferon: there are a number of varieties of domestic, including sairogin, andafin, kain yisheng, far cetin, far dein, levon can and so on, the most sales should be sairogin. The effectiveness of the domestic interferon may vary somewhat between different varieties and individuals, but the difference is not significant. The price of domestic interferon is relatively cheap, if the case is properly selected, the use of domestic interferon often also obtains better results, economic difficulties are more suitable. The actual nucleoside (acid) analogs: advantages: direct antiviral effect is stronger, less side effects. In addition to slow hepatitis B, can also be used for liver failure and decompensated cirrhosis, oral convenience does not require injection. Disadvantages: poor long-term efficacy, easy to relapse after discontinuation, difficult to fix the course of treatment, long-term use can produce viral mutation, drug resistance. The following nucleoside (acid) analogues are commonly used in clinical practice: 1, lamivudine: early application, strong antiviral effect, less side effects, but long-term use of the drug because the virus is prone to mutation (YMDD mutation) and drug resistance. Currently, it is not used as the first choice of antiviral drug for chronic hepatitis B. The first step in the process is to use the drug for the first time as much as possible because it is prone to mutation. 2. Adefovir: The incidence of resistance is low, but the antiviral effect is not strong, and long-term application may have an impact on kidney function, especially in people with underlying kidney disease. In addition, long-term application can cause hypophosphatemia, so long-term users every 3 – 6 months to check the blood phosphorus level, while checking kidney function. 3.Tibivudine: strong antiviral effect, characterized by easy to obtain E antigen conversion (seroconversion, i.e., major triplet to minor triplet), can also be used during pregnancy, there are reports that the drug can improve renal function, so hepatitis B with renal impairment is the most suitable; but also relatively easy to produce resistance, although the emergence of muscle lesions during the use of drugs is rare, but still need to regularly check the serum creatine kinase (CK), and can not be The drug can be used in combination with interferon. 4, Entecavir: strong antiviral effect, the incidence of viral mutation is very low, currently can be listed as the first-line antiviral hepatitis B drugs. Side effects are very low, but the long-term application of a very small number of patients may appear hyperbilirubinemia. 5, tenofovir: the advantages are: stronger antiviral effect, less side effects, very low incidence of viral mutation, reproductive needs can also be used, but the price is more expensive, if the economy can be classified as the first-line antiviral hepatitis B. Disadvantages: there is a potential impact on kidney function, during the drug still need to regularly check kidney function.