Celecoxib is a non-steroidal anti-inflammatory drug. Non-steroidal anti-inflammatory drugs are anti-inflammatory drugs that do not contain steroidal structure, mainly through the inhibition of cyclooxygenase enzyme to inhibit prostaglandin synthesis, to play a role in anti-inflammatory and pain relief. Celecoxib works mainly by inhibiting cyclooxygenase-2 and does not inhibit cyclooxygenase-1 and cause significant gastrointestinal discomfort, and the gastrointestinal response is much lower than other NSAIDs. Therefore, the gastrointestinal side effects of this drug are relatively small. Celecoxib is mainly used in clinical practice to relieve the symptoms of osteoarthritis, and its effect is more obvious for the pain symptoms caused by osteoarthritis, rheumatoid arthritis and ankylosing spondylitis. In addition, celecoxib is also effective for pain relief after orthopedic surgery. Celecoxib may also cause certain adverse reactions, such as allergic rash, nausea, vomiting, dizziness, headache, stroke, myocardial infarction, etc. Therefore, celecoxib should not be used in patients with severe heart failure and active peptic ulcers, and the specific use of the drug should be under the guidance of a doctor, not self-medication, so as not to adversely affect the health of the organism.