What are the symptoms that are easily confused with premature pubic hair development? Here’s what you need to know: Axillary and pubic hair loss: Sheehan’s syndrome – Hypopituitarism (Simon-Shihan syndrome) is a clinical group of signs presented by inadequate secretion of adeno-pituitary hormones due to multiple etiologies, secondary to low glandular, thyroid, and adrenal cortical function. Hypoadrenocorticism – when the vast majority of the adrenal glands on both sides are destroyed and various manifestations of corticosteroid deficiency occur, it is called hypoadrenocorticism. Loss of axillary and pubic hair can occur in all of the above diseases. Absence of bearded axillary and pubic hair: seen in Klinefelter syndrome. Also known as congenital testicular hypoplasia or Klinefelter’s syndrome. The typical karyotype is 47, XXY. The phenotypic features include testicular hypoplasia. The body is elongated, due to an increase in the distance between the heel and the toe bones. In men, the mammary glands are developed, pubic hair is distributed in a feminine pattern, and the penis and testes are small. Severe cases are associated with mental retardation, cryptorchidism and hypospadias. Infantile vulva without pubic hair: Commonly seen in patients with Turner syndrome, also known as congenital ovarian hypoplasia syndrome, which is the only known sex chromosome monosomy disorder. The patient has a female phenotype, short stature, generally normal intelligence, but often lower than her siblings, triangular face, often with ptosis and medial canthus, narrow maxillary prominence, small and receding mandible, shark-like mouth with downward rotation of the corners of the mouth, low hairline of the neck that extends all the way to the shoulders, webbed neck in about 50% of patients, wide shoulders, flat chest like a shield, poorly developed nipples and mammary glands, wide spacing between the nipples. Elbow valgus is typical in this disease, the fourth and fifth metacarpals are short and inwardly curved, and there is often underdeveloped nails. Lymphomatous swelling of the dorsum of the foot during infancy is very unusual. The abnormalities of the genitourinary system are mainly poorly developed ovaries (corpus gondii), no follicle formation, and an underdeveloped uterus, often presenting for primary amenorrhea. Patients with hypovarianism have sparse pubic hair, no axillary hair, and infantile external genitalia due to their low ovarian function. In addition, approximately 1/2 of patients have malformations such as aortic stenosis and horseshoe kidney. A detailed and complete medical history is taken and includes the development of sexual characteristics, vaginal bleeding, and the presence of endocrine medication. Measurement of follicle-maturation hormones FSH and LH in blood by radioimmunoassay can help to differentiate between true and false precocious puberty. In cases of somatic precocious puberty, the ovaries may be enlarged and have cystic changes. If adrenocortical disorders are suspected, posterior glandular wall inflation imaging may be performed. The frontal and lateral images of the head can be used to observe the size of the pterygoid saddle to exclude tumors.