With the development of society, environmental pollution is getting heavier and heavier, and work and life are becoming more and more stressful, the incidence of male azoospermia is also getting higher and higher. It is well known that sperm play a very important role in the fertility process, and azoospermia patients often give up treatment because they do not understand the treatment, which brings misfortune to many families. Currently azoospermia accounts for 1% of the population of fertile men, and about 8.3% to 30% of male infertility is caused by azoospermia, which is one of the most serious and major causes of male infertility. There are two types of azoospermia: true azoospermia is due to atrophy and degeneration of testicular spermatogenic cells, which cannot produce sperm, also known as congenital azoospermia; the main causes are: hereditary diseases, congenital testicular abnormalities, testicular lesions, serious systemic diseases and malnutrition, radiation injuries and endocrine diseases, etc. 2. Pseudo-aspermia is a condition in which the testes can produce sperm but the sperm cannot be discharged due to obstruction of the vas deferens. The main causes are: obstruction caused by cysts at the epididymis pressing on the epididymal duct, obstruction of the vas deferens due to injury, congenital malformation, infection, etc. How can these patients have their dream of fatherhood? Most of the patients will first think of herbal or surgical treatment, of course, there are also those who can get pregnant, but most of this disease is irreversible, that is, it is difficult to be cured, which belongs to the category of absolute infertility. At present, the treatment of azoospermia can be divided into two categories according to the specific situation of the patient: First: for patients with pseudospermia, the blocked vas deferens can be improved by medication or surgery, and if the result is not good, testicular or epididymal puncture for sperm extraction can be attempted, and after obtaining sperm, the second generation of IVF can be used to help conceive, that is, microinjection of single sperm in the oocyte plasma to obtain a real child of their own. This method is simple and easy to use, and the current IVF technology is mature and has a high pregnancy rate for assisted conception. The second category: For patients with true azoospermia, it is generally difficult to improve through surgery or medication, and most of these patients often give up because they cannot be treated, or become sterile for life or adopt other children, so is there really no good treatment? Of course not. At present, there are many human sperm banks approved by the Ministry of Health in China, mainly to solve the fertility problem of male azoospermia patients. If a man is diagnosed with true azoospermia, he can use the sperm from the human sperm bank to make his wife pregnant. In the first case, if the woman is basically normal and her fallopian tubes are open, donor insemination can be considered, which means that sperm is injected directly into the woman’s uterine cavity to help her conceive through the natural union of sperm and egg. If the woman’s fallopian tubes are blocked or if there are other indications for IVF, then donor sperm IVF can be considered, and the procedure is the same as conventional IVF. These are the main methods of fertility assistance for patients with azoospermia. Patients can choose the method that is suitable for them after consulting with their doctors according to their specific conditions. To sum up, it is not true that there is no good treatment or pregnancy assistance method for male azoospermia patients, so don’t give up, find out the cause of azoospermia and choose the appropriate treatment and pregnancy assistance method according to your specific situation.