The two organs where prostate cancer is most likely to metastasize are the bones and lymph nodes, and the bones that are most likely to metastasize are the spine and pelvis. Once the bone metastasis of prostate cancer occurs, there are the following points in treatment: 1) overall treatment for prostate cancer: endocrine therapy first, which can control both the primary lesion and the metastasis of bone, is the most basic treatment choice; 2) chemotherapy: patients with bone metastasis of prostate cancer generally have high malignancy of tumor, so if endocrine therapy alone, the effectiveness or duration of treatment will be shorter. Radiotherapy: There are many kinds of radiotherapy, if the bone metastasis is metastatic, you can choose the internal radiotherapy with nuclear hormones, because these nuclear hormones with isotopes will selectively combine with the bone metastasis and kill the cancer cells in the metastasis through radioactive rays to achieve the purpose of tumor control. On the other hand, if the skeletal lesions are relatively single, you can choose to remove the metastases or do external radiotherapy.