Cranial repair surgery is a relatively common and routine surgical procedure that can be performed in large hospitals around the world. However, the cranial bone repair material used in most hospitals for cranial bone repair surgery is basically titanium mesh. Titanium mesh is a metal material, and human tissue compatibility is not very ideal, may cause postoperative rejection, infection phenomenon, scalp ulceration, resulting in titanium mesh exposed in the outside; titanium mesh is a cover type of repair, titanium mesh edges may cause wear and tear on the scalp, a long time the titanium mesh may be deformed by the force of the local bulge, and so on, which may also cause titanium mesh exposed. Cranial repair titanium mesh exposed how to do? Ms. Peng from Jiangxi is one of the patients with exposed titanium mesh after cranial repair, what did she do? She was 11 years ago because of head trauma craniotomy de-bone flap decompression surgery, resulting in a large area of the left fronto-temporal top of the skull defect, in the local use of titanium mesh material for skull repair. After the repair surgery, she had been quite stable and had no discomfort. However, a month or so ago, the skin on her forehead broke down and the titanium mesh material was slightly exposed, but no special treatment was given at that time. Later on, the ulcer expanded and became more and more serious, so she hurriedly sought treatment. The local hospital suggested replacing the repair material, but it needed to be done in two surgeries, first surgery to remove the material, and then surgery again for the new material after the scalp had grown back in half a year. She didn’t accept it, but after learning from various sources that we can replace the material in one operation, she came to Beijing for treatment. After detailed diagnosis and evaluation, the patient was able to design and prepare a personalized PEEK material by using a special technique of 3D reconstruction before the surgery, and then the titanium mesh material was removed and the PEEK material was inserted at the same time in one operation, and during the operation, the frontal skin ulceration was treated with aesthetic plastic surgery (flap release), which resulted in a good effect. The patient was very satisfied after the operation and was discharged from the hospital about ten days later. So, what about the exposed titanium mesh for cranial repair? That is the need for timely replacement with new materials. At present, our widely used polyether ether ketone PEEK material is a kind of cranial bone repair material with excellent performance, which overcomes the various problems of titanium mesh material very well, and the postoperative effect is very good. Therefore, after the cranial bone repair titanium mesh is exposed, it is generally recommended to replace it with PEEK material. Our team can complete the replacement of PEEK material in one operation, which greatly reduces the patient’s injury and financial burden.