The pathological basis of diabetic foot is the occlusion of small and medium-sized blood vessels caused by long-term hyperglycemia, and then tissue ischemia and necrosis. Therefore, the treatment of diabetic foot is based on good control of blood sugar, and in addition, specialized treatment should be done for peripheral vascular lesions. The goal of prevention and treatment of diabetic foot is prevention-oriented, early diagnosis and early treatment, which not only can significantly improve the quality of life of diabetic patients, but also can greatly reduce the related medical expenses, which has important social and economic benefits. 1.Basic treatment (1) Absolute abstinence from smoking, weight control, strict control of blood sugar, insulin application is preferable, active correction of ketoacidosis, heart, brain, kidney complications and various adverse factors affecting the healing of gangrene. (2) Local debridement: removal of necrotic tissue, daily routine disinfection and dressing changes, etc. (3) Strengthen patient education, reasonable foot care and prevention of damage from the outside. 2.Anti-infection treatment Diabetic foot is highly susceptible to infection due to tissue ischemia and reduced resistance, as well as being in a high glycemic state. Due to the inaccessibility of blood vessels, drugs cannot be effectively transported to the infection site, so the infection is often difficult to control, and sometimes even sepsis occurs. Among the pathogenic bacteria, Staphylococcus aureus is common, followed by Streptococcus, Enterococcus, Bacillus and anaerobic bacteria, etc. Among the drug-resistant bacteria, Pseudomonas aeruginosa is more common. After admission, take the secretion of the lesion for bacterial culture as early as possible, treat with broad-spectrum antibiotics first, and change to sensitive antibiotics after the culture result. 3.Treatment of ischemic foot ulcer (1)For those whose vascular lesions are not very serious or without surgical indications, they can be treated by conservative internal medicine and use vasodilator drugs. (2) For those with severe vascular lesions, on the basis of conservative treatment, interventional therapy, i.e., endoluminal revascularization, should be performed to regain blood supply to the distal ischemic tissues. The vascular condition of the lower extremity must be accurately evaluated before interventional treatment so that the physician can adequately prepare and achieve a successful procedure. The most advanced Dazzle dual-source CT is now available to further differentiate tissue types and characterize lesions such as atheromatous plaques, and is the test of choice prior to arterial intervention. Previously, diabetic infrapopliteal vascular lesions were so small that surgeons were often unable to do anything about them. Since 2005, Zhang Qiang, director of the Department of Vascular Surgery at Shanghai Oriental Hospital, has been the first in China to explore the use of the DEEP sub-knee micro-balloon from Italy to perform balloon dilatation and shaping of the sub-knee vessels (including the arteries of the foot) in the affected limbs, and the patients’ clinical symptoms can be significantly improved with great success. (3) For patients with gangrene who have pain at rest and extensive vascular lesions that cannot be revascularized, toe amputation or amputation should be performed if necessary, and patients who already have limb necrosis should be amputated promptly after the plane of necrosis is clear. Patients with suprapopliteal arteriopathy need to undergo arterial balloon dilation + stent implantation before amputation to open the vessels and avoid the amputation incision from healing due to ischemia. 4.Treatment of neuropathic foot ulcers (1) Changing abnormal stress on the foot 90% of neuropathic ulcers can be healed by reasonable conservative treatment. The key to treatment is to reduce the pressure caused by the primary disease, and to understand the pressure distribution by means of a foot manometer, and then use special orthopedic shoes or orthoses to change the pressure in the patient’s foot. (2) Improve nerve function B vitamins and nerve growth factors are available to promote nucleic acid and protein synthesis in nerve cells and myelin formation for axonal regeneration. (3) Covering dressing Dressing can prevent further damage to the wound, reduce the risk of infection, and maintain the ideal environment for wound healing. Wet dressing can be chosen to improve the growth rate. 5, amputation Active treatment still occurs limb gangrene, should be promptly amputated, amputation site should be accurately estimated, local circulation should be made to choose, to ensure good circulation height. The mortality rate of amputation due to diabetic foot artery occlusion is high, so it should be treated actively as early as possible to avoid the surgical risk of amputation.