When suffering from kidney stone disease combined with effusion, the best treatment options are as follows: First, if the effusion is mild and the stone diameter is less than 2cm, lithotripsy by extracorporeal shock wave will be performed for a review in about 7 days to observe whether the stone is discharged and whether there is any change in the kidney effusion. Secondly, if the diameter of kidney stone is greater than 2cm and the fluid is moderate or above, percutaneous nephrolithoscopy or holmium laser lithotripsy under ureteroscope can be used to treat the stone by placing ureteral stent tube to drain the fluid in the kidney first and treat the stone at an optional stage. Thirdly, if you have kidney stones combined with severe hydronephrosis, you need a deadline to remove the stones as early as possible through surgery to solve ureteral obstruction and protect the kidney function as much as possible. For the treatment of hydronephrosis with kidney stones, different plans need to be implemented according to the specific situation, but it is important to seek medical attention in time to avoid delaying treatment.