Patients with hepatitis B who are planning to conceive should know the following about hepatitis B pregnancy in order to have a healthy baby: 1. Patients with chronic hepatitis B who have fertility requirements should try to apply interferon or NAs treatment before conception if there is an indication for treatment, with a view to completing treatment 6 months before conception. Reliable contraception should be used during the treatment period. 2. In patients with hepatitis B exacerbations during pregnancy, mild elevation of ALT can be closely observed, and in those with more severe liver lesions, TDF or LDT antiviral therapy can be used after weighing the pros and cons. 3. Patients with unintended pregnancy during antiviral therapy are advised to terminate the pregnancy if interferon therapy is applied. If oral NAs drugs are applied: if the drugs applied are pregnancy grade B drugs (LDT or TDF) or LAM, treatment can be continued with full communication and trade-off; if ETV or ADV are applied, with full communication and trade-off, treatment needs to be continued with TDF or LDT instead, and termination of pregnancy is not recommended. If HBV DNA load is greater than 2×10^6 IU/ml in the middle and late stages of pregnancy, TDF, LDT or LAM treatment can be started in the 24th-28th week of pregnancy to reduce mother-to-child transmission. It is recommended to discontinue the drug 1-3 months after delivery and breastfeeding is possible after discontinuation. 5. Male patients with hepatitis B treated with interferon should be considered for fertility only 6 months after discontinuation of the drug; male patients treated with antiviral therapy with NAs, there is no evidence of adverse effects of NAs treatment on sperm, and fertility can be considered with adequate communication with the patient.