Many patients panic after learning that they are infected with HPV (human papillomavirus), believing that being infected with HPV means having a sexually transmitted disease and having condyloma acuminata. In fact, this view of patients is wrong. First of all, let’s have a proper understanding of what HPV really is. Human papillomavirus (HPV), an epitheliophilic virus, is widely distributed in humans and animals, with a high degree of specificity, it is a small DNA virus, 45-55nm in diameter, the coat is icosahedral three-dimensional symmetry, containing 72 shell particles, there is no vesicle membrane. Clinically, there are up to dozens of subtypes of HPV, and different subtypes can cause different diseases. HPV can be divided into two categories, low-risk and high-risk, depending on the degree of pathogenicity or cancer risk of HPV subtypes. Low-risk HPV mainly causes ectopic warts on the anal skin and male genitalia, female labia majora and minora, urethra, lower vagina, and low-grade cervical intraepithelial neoplasia, with viral subtypes HPV6, 11, 30, 39, 42, 43, and HPV44. High-risk HPV causes external genital warts and, more importantly, external genital cancer, cervical cancer and high-grade cervical intraepithelial neoplasia, mainly HPV types l6, 18, 31, 33, 35, 45, 51, 52, 56, 58 and HPV 61. Common clinical conditions include: common warts (mainly types 1, 2, and 4) called wart or wart, which can occur anywhere, with the hands being the most common. Plantar warts (mainly types 2 and 4) grow underneath the callus and are painful to walk on. Flat warts (mainly type 3, 10) occur on the face, hands, arms, knees, and more frequently. HPV 16, 18, 33 and other types are closely related to the occurrence of cervical cancer, and the rate of HPV DNA positivity in cancerous tissue detected by nucleic acid hybridization is more than 60%. The rate of HPV DNA positivity in cancerous tissue detected by nucleic acid hybridization is over 60%. HPV infects humans mainly through direct or indirect contact with contaminated objects or sexual transmission. After the virus invades the body, it stays in the skin and mucous membranes at the site of infection and does not produce viremia. Within 1-2 months of the appearance of the infected lesion, the blood produces the corresponding antibodies against the infected virus, and at this time, if a blood test is taken, the result will be positive, and the positive rate is about 50%-90%. However, this positive result is only positive for antibodies, not for the virus. In other words, what is detected in the blood is the corresponding antibodies against HPV, not the virus itself, because the virus lives only in the superficial mucous membrane of the skin at the site of infection and is not normally found in the blood. Regardless of the type of HPV infection, antibodies will be present in the serum after a period of time. The antibodies persist for months to years after the lesions have subsided, but are not protective. In other words, an average person with a wart who has a blood test for HPV is likely to have a positive result. However, this positive result does not mean that the person has an STD or condyloma. So, when a patient has a positive blood test, it only means that the HPV antibodies are detectable in the blood, not the virus. It means that at some time in the past, the patient has been infected with the HPV virus, but not necessarily the type of strain that causes the STD condyloma acuminatum, and not necessarily condyloma acuminatum or STD.