Patients with diabetic foot grade 0 are those who are at high risk of developing a diabetic foot ulcer, even though they have not yet developed a diabetic foot ulcer. It generally includes peripheral vascular disease, peripheral neuropathy, or both. The clinical manifestations of diabetic peripheral neuropathy and peripheral vascular disease vary greatly depending on their predilection. The main manifestations of peripheral vasculopathy are: abnormal skin color; cold legs and feet, reduced skin temperature; pale feet when elevated, purple-red when lowered; weak or absent dorsal foot and posterior tibial artery pulsations when touched; pain in the lower extremities may occur after a short period of activity, relieved after rest, and again when moving again; severe pain even at rest, especially at night. Peripheral neuropathy is also different from sensory neuropathy, motor neuropathy and autonomic neuropathy, which can appear separately or simultaneously: common symptoms of sensory neuropathy: no pain sensation after tingling or ulceration of the foot; reduced tactile sensation, numbness and coldness of the hands and feet; inability to feel external temperature stimuli such as cold, warm or hot, and easy to develop burns or frostbite; ankle sensation, walking on cotton, etc. Common symptoms of motor neuropathy: atrophy of foot muscles and subcutaneous tissues, curvature of interdigital joints, formation of claw-shaped toes, corns or calluses on the soles of the feet, and foot deformities. The change in foot shape can lead to changes in the weight-bearing parts of the foot, and the deformed areas are also prone to pressure injuries. Common symptoms of autonomic neuropathy: sweaty or less sweaty skin on the extremities; dry, keratinized, brittle skin, often prone to fissures, thinning and shiny, poor elasticity, blisters, etc. It is also prone to co-infection. As mentioned earlier, peripheral vasculopathy and peripheral neuropathy may appear at the same time, with a variety of clinical manifestations. It is important to check one’s feet frequently to detect signs when one or more of the above symptoms appear, and to be able to seek medical attention early to prevent further development of the lesion.