What drugs are used to treat lower limb edema should be treated symptomatically with the specific cause of the patient: first, caused by heart failure, left heart failure, right heart failure can cause lower limb edema, in addition to the treatment of the underlying disease, the most important thing is to apply diuretics. Commonly used diuretics such as torasemide, furosemide, spironolactone, etc. Secondly, lower limb venous thrombosis, due to lower limb venous thrombosis, leads to lower limb edema due to obstruction of venous return, and the aim of treatment is to melt the thrombosis of lower limb veins. Commonly used drugs include rivaroxaban, warfarin, etc. Thirdly, lower limb edema caused by drugs, most commonly occurs in patients with hypertension who apply calcium antagonists, such as nifedipine and amlodipine. The solution to this problem can be to switch to other antihypertensive drugs, such as Irbesartan hydrochlorothiazide, which has a diuretic effect on swelling while lowering blood pressure.