20% of renal tubular atrophy is severe. Renal tubular atrophy is generally indicative of diseases such as glomerulosclerosis and interstitial fibrosis. Patients at this time may have abnormal test values such as positive urine sugar, low specific gravity urine, alkaline urine, amino acid urine, and elevated blood creatinine. With the development of the disease, it can progress to uremia. Common causes of renal tubular atrophy are chronic kidney disease, drug damage, toxins, toxic stimulation, renal artery stenosis, obstructive diseases, infectious diseases, autoimmune-related diseases, etc., which need to be standardized according to the specific causes of early treatment. At the same time, it is recommended that patients should avoid staying up late, pay attention to rest, high quality protein diet, careful use of nephrotoxic drugs during the treatment period. Patients with renal tubular atrophy should consult a regular hospital as soon as possible and under the guidance of a doctor.