Accidents can happen everywhere in life, and some people suffer from cranial defects as a result of these accidents. The role of skull is irreplaceable and skull defect must be repaired for better health. In order to ensure that the skull repair surgery is more effective, the best skull defect repair material should be chosen. Cranial defect should not be taken lightly, if not treated in time, it will lead to a series of neurological dysfunction and induce some syndromes, such as dizziness, nausea and coldness, loss of limb strength and other symptoms. Also, cranial defects can lead to severe cerebral edema, causing local ischemic necrosis of the brain and various neurological localization symptoms. Therefore, once skull defect occurs, timely examination and treatment in regular hospital is the key. In the process of skull repair surgery, there are many factors that affect the post-operative effect, such as the time of surgery, the hospital chosen, experts and materials, etc. Generally speaking, most of the skull damage caused by trauma or surgery should be repaired after three months. There are many materials for skull repair surgery, such as plexiglass in the early stage, bone cement and titanium alloy in the later stage. However, after a series of clinical verification, these common materials have certain defects and patients will have various physical rejection reactions after surgery, so it is necessary to choose a safer material in order to achieve better postoperative results. In the choice of skull repair materials, some hospitals have carefully researched and adopted the new PEEK material, which is safer and more advanced, hard and flexible, and not easily deformed. This PEEK material can be well insulated, stable, three-dimensional shaping, and has an extremely high degree of fit, making it a good choice for skull repair surgery.