Cranial defect is a relatively common disorder in neurosurgery. We live in a complex environment with various dangers and risks everywhere, such as traffic accidents, production safety accidents, falling objects and so on, plus some cranial diseases that people have to undergo craniotomy, all these factors may eventually cause the loss of the skull. Missing part of the skull will cause great harm to human body. First of all, the lack of hard skull protection, then the brain is easy to be attacked by the outside world, such as the impact of external sharp objects or bump, etc., may directly injure the brain tissue, and even endanger life; In addition, the lack of skull will also make the intracranial environment change rapidly, the intracranial pressure is unstable, the intracranial blood circulation, cerebrospinal fluid circulation and other interference, brain nerve function can not play and run normally, will produce a series of skull It is also important to note that the loss of part of the skull will cause unattractive skull appearance, which is of concern to many patients, and may even produce low self-esteem and depression. Therefore, after skull loss, it is necessary to carry out skull repair in time. How long does it take to repair skull loss? After skull loss, skull repair surgery is needed in time, usually after about two or three months after the defect. This two to three months time is necessary to wait because it needs the patient’s scalp to recover and the patient’s body condition to recover gradually so that it can tolerate another skull repair surgery, especially the debridement surgery performed by many patients in the first stage because of intracranial hypertension, then it needs more 2~3 months time to make the intracranial pressure to return to normal level before the skull repair can be performed. So this two to three months waiting time is necessary, but not too long, if the longer time will cause other problems, such as some patients will cause meningeal brain expansion, some patients will have serious collapse of the scalp, producing a series of cranial defect syndrome, like dizziness headache and other symptoms. That’s why will repair surgery needs to be performed in a timely manner. Currently our team uses a very advanced polyetheretherketone peek material to perform the skull repair. Polyetheretherketone is a new type of special polymer material, its properties are very close to the human autologous skull, and it can be customized according to the patient’s skull structure with personalized three-dimensional design, highly restoring the patient’s skull shape. The team also continuously carries out technical improvement and innovation and material optimization design, and innovatively introduces the concept of aesthetic plastic surgery, so as to carry out comprehensive peek cranioplasty, which can achieve the triple effect of anatomical integrity, beautiful appearance and perfect function, and is well received and recognized by the majority of patients and their families.