People should know that the skull has a very important role to play in protecting human life. The emergence of the problem of cranial defects will lead to the lack of protection of brain tissue, and the impact is extremely large. Therefore, when a skull defect occurs, it is necessary to go to a regular hospital to do skull repair, so that life safety can be guaranteed. Cranial repair surgery should pay special attention to the choice of repair materials, good materials to achieve better repair results. Titanium mesh is a widely used material in clinical practice. The use of this material is more advanced than that of early artificial bone and plexiglass, but there are also many problems. Does the use of titanium mesh for cranial bone repair have any adverse effects on the future? Mainly manifested in the following aspects: 1, with titanium mesh for cranial bone repair, postoperative patients will be infected, there will be a rejection reaction, and even lead to patients with scalp tissue damage, titanium mesh material directly exposed, etc.. 2, because the titanium mesh is a metal material, its thermal insulation performance is not very good, after the operation, the patient will be very sensitive to the external hot and cold environment, will bring a lot of discomfort to the patient. 3, the use of titanium mesh material for cranial repair is covered repair, the edge of the material is prone to cause some irritation and damage to the scalp tissue. 4, titanium mesh material is not hard enough, because of the impact of external forces after the operation is prone to collapse. 5, the use of titanium mesh material will interfere with the radiation penetration, which will affect the postoperative CT MRI and other tests, interfering with the diagnosis. In view of the use of titanium mesh for cranial bone repair surgery will appear above all these problems, the urgent need for safer materials, peek is currently more ideal. peek material is very good to overcome these problems of titanium mesh material, is a polymer material, performance and autologous cranial bone equivalent to the postoperative effect with the same as normal people.