B-type natriuretic peptide, also known as brain natriuretic peptide, or BNP for short, is a biologically active natural hormone synthesized by cardiac myocytes and expressed mainly in the ventricles, but also in brain tissue. When the left ventricle is not functioning properly, it is rapidly synthesized and released into the bloodstream due to the expansion of the myocardium, which helps regulate the function of the heart. BNP secreted by cardiomyocytes first exists as a precursor consisting of 108 amino acids, and when cardiomyocytes are stimulated, it is cleaved by activating enzymes into an inactive linear polypeptide consisting of 76 amino acids and an active cyclic polypeptide consisting of 32 amino acids, which are released into the blood circulation and are called NT-proBNP and BNP, respectively. b-bnp is mainly used for the diagnosis of heart failure, monitoring the progress of the disease, and for the treatment of heart failure. B-BNP is mainly used to diagnose heart failure, monitor the progression of the disease, evaluate the efficacy and prognosis, and also to assess the status of cardiac function and its recovery in patients with acute heart attack.
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