Chronic granulocytic leukemia, or chronic granulocytic leukemia, is the most common type of chronic leukemia. Chronic granulocytic leukemia is a common type of chronic leukemia. Chronic granulocytic leukemia has a slow onset with no obvious symptoms in the early stages, and is often diagnosed by incidental finding of splenomegaly or abnormal white blood cells during physical examinations or visits for other diseases. Chronic granulocytes can be clinically divided into chronic, accelerated and acute phases. Patients who present with clinical and hematologic manifestations of acute leukemia are referred to as slow-onset patients. Most patients have a median survival of 3-4 years without bone marrow transplantation or Gleevec therapy. The prognosis is extremely poor after the occurrence of acute changes in slow granules. Treatment principles 1, chemotherapy; 2, Gleevec therapy 3, bone marrow transplantation. Specific medication principles 1, for typical chronic stage patients if the economic conditions are good can prefer Gleevec treatment, 3-6 months after treatment to check the chromosome and fusion gene, if the chromosome does not turn negative in 6 months, 12 months gene does not turn negative, it is recommended to receive bone marrow transplantation as soon as possible. 2. For accelerated phase and acute change phase should receive Gleevec treatment as per. Receive bone marrow transplantation as soon as possible after recovery to the chronic phase. If the economic conditions are not so good, it is recommended to receive transplantation as soon as possible. 3. Hydroxyurea therapy should be applied to patients with poor economic conditions.