Thyroid parenchymal echogenicity is uneven, indicating that the density inside the thyroid gland is uneven, which can be seen in Graves’ disease, autoimmune thyroid disease, thyroid nodules, etc., and needs to be diagnosed with relevant examinations and adopt appropriate drug treatment, radioactive iodine chemotherapy and surgery. 1. Graves’ disease: diffuse thyroid lesions with uneven echogenicity of the thyroid parenchyma can be seen, which is usually treated with antithyroid drugs such as methimazole, radioactive iodine and surgery. 2. Autoimmune thyroid disease: such as Hashimoto’s thyroiditis, such as only goiter without hypothyroidism does not need treatment, hypothyroidism needs to be supplemented with levothyroxine sodium tablets as replacement therapy. 3. Thyroid nodules: there are benign nodules and malignant nodules, benign nodules without obvious symptoms only need to observe and follow up, regular review, malignant nodules and benign nodules with symptoms such as compression need timely surgical treatment. It is recommended that patients with uneven echogenicity of thyroid parenchyma should go to regular hospitals, complete relevant examinations, and standardize the diagnosis and treatment under the guidance of doctors to avoid delaying the condition.