Sore bones all over the body can be caused by a variety of reasons. You should not judge whether it is a precursor of leukemia simply based on this symptom, but need to combine it with other symptoms to clarify the cause in time. The whole body bone pain may be caused by chronic strain of local ligaments, fascia, tendons and muscles, and also related to fever and muscle lesions and neuropathy, not necessarily the manifestation of leukemia. While leukemia belongs to a malignant disease of the blood system, clinical symptoms such as anemia, fever, bleeding and enlargement of liver, spleen and lymph nodes are often present, and most patients will have crushing pain in the sternum. Patients are advised to visit the rheumatology department or related departments of regular hospitals. Targeted blood routine, blood smear, biochemistry full test, anti-nuclear antibody, anti-cyclic citrullinated peptide antibody and other related tests, and if necessary, bone marrow aspiration can be done to clarify the diagnosis and treatment and exclude local symptoms and signs.