The swelling of the lips found after waking up is generally more common in the clinic, and the specific causes include the following: firstly, it may be allergic inflammation of the lips, which is prone to local mucosal redness and swelling after waking up, and the swelling can be relieved by taking oral anti-allergy drugs or eating antihistamines such as cetirizine. Secondly, it may be due to the inflammation of the lips resulting in an irritation reaction. As the local mucous membrane is easily infected with bacteria after the acute phase of redness, swelling, heat and pain, anti-inflammatory and symptomatic treatment should be carried out, and local hot compresses can be applied to reduce the inflammation and swelling. Then, atopic infections may also cause swelling of the mouth and lips, such as inflammation in the oral mucosa and apical abscess, or inflammation of the pharynx may cause swelling of the mouth and lips. Therefore, if you find swollen lips after waking up from sleep, it is best to go to a regular hospital to find out the cause and carry out systematic and standardized treatment according to the cause.