There are many orbital diseases in which either compression or erosion can cause breakage of the orbital and periorbital bone or result in orbital deformity. Sometimes surgery for many orbital diseases also requires removal of some bone, which can cause orbital and periorbital bone defects and deformities. Orbital bone defects and orbital deformities caused by postoperative orbital and periorbital diseases can be observed without treatment if they are minor and do not affect function and if the patient does not have high requirements for appearance. If they affect the function of the eye and periorbital area or significantly affect the appearance, they need to be treated with early surgery. If the bone defect is too large and the deformity is severe, traditional treatment methods are ineffective or impossible to treat. Computer-aided design and fabrication techniques allow for individualized treatment of complex orbital and periorbital diseases. The orbital bone defect and deformity can be successfully predicted before surgery, and the orbital bone defect and deformity can be prepared for treatment before surgery and treated and repaired together with the orbital disease during surgery, with remarkable results.