Itchy skin on hands and feet at night may be caused by eczema, urticaria, tinea pedis, diabetes, kidney disease, liver disease and other factors, and you need to consult a doctor in time to clarify the cause of the disease and treatment. 1. Eczema: If the crevices of fingers and toes are not cleaned in time after sweating, it is easy to cause eczema, redness, swelling, itching and other symptoms, and in severe cases, small blisters may also appear. 2. Urticaria: If allergies are caused by diet, environment and other factors during the day, thus triggering urticaria, it may appear in the hands and feet area of the wind, itching and other symptoms. 3. Ringworm: If you live in a humid environment or do not pay attention to personal hygiene, it may lead to fungal infections, which may cause ringworm, blisters, vesicles, itching, odor and other symptoms in the hands and feet. 4. Diabetes mellitus: diabetic peripheral neuropathy can appear skin itching and other sensory abnormalities, mostly seen in both upper limbs and lower limbs. 5. Kidney disease: advanced kidney disease toxins gathered in the body can not be discharged from the body, the skin and subcutaneous nerve irritation, skin itching symptoms can occur. 6. Liver disease: Liver disease leads to liver damage, which affects the blood sugar level in the body, leading to increased blood sugar level and itchy skin. In addition, vegetative nerve dysfunction may also cause itchy skin on the hands and feet, it is recommended that the patient consult a doctor in a timely manner, after a clear diagnosis of the cause of the disease, and actively cooperate with the treatment, so as not to delay the condition.