Craniocerebral trauma is the result of violence to the head and brain and includes three conditions: direct injury to the skull and brain tissue, secondary damage to brain tissue, and damage to adjacent soft tissue. Headache is a common symptom after traumatic brain injury, so why does this happen? Because after these injuries occur in the skull, these injurious stimuli act on pain-sensitive structures in the skull, such as the arterioles, venous sinuses, dura mater, certain cranial nerves, and possibly on the scalp, vascular nerves in the hair, periosteum of the skull, and muscular nerves in the neck. These stimuli cause nociceptive substances such as 5-hydroxytryptamine, prostaglandins, interleukins, and substance P to act on nociceptive receptors, which have only a cytoplasmic coating on their surface and can come into direct contact with tissue fluid to produce nociceptive signals. Nociceptive signals are transmitted to the cortical sensory centers in the postcentral gyrus via the trigeminal thalamus, posterior thalamic nucleus, and internal capsule to produce nociception. Among them, the nucleus accumbens, thalamus, hippocampus and cingulate gyrus of brainstem are involved in the integration and adjustment of nociception. Warm tip: For post-traumatic headache, while dealing with the primary injury, some measures can be taken, and patients should cooperate with the doctor and follow the medical prescriptions for treatment.