Mycoplasma infections are caused when a person comes into contact with an object carrying mycoplasma or an infected patient, and there are multiple routes of infection. Droplet transmission is one of the major routes of infection for mycoplasma infections. This type of transmission occurs mainly from person to person, and the infectious species is mostly Mycoplasma pneumoniae. When a person with Mycoplasma pneumoniae pneumonia coughs or spits out saliva, the droplets carry mycoplasma, and mycoplasma infections can occur when other healthy people inhale them. Many infections also occur when a person touches other objects, such as contact with water and soil contaminated with mycoplasma. People who swim in ponds or pools containing mycoplasma may also become infected with a variety of mycoplasmas, including Mycoplasma genitalium and Mycoplasma pneumoniae. Sexual transmission is also more common in mycoplasma infections, and the type of mycoplasma infected is mostly active at the human genitalia or urethral area. In addition, mother-to-child transmission is also a mode of infection, and if a mother is infected with mycoplasma, the baby can be infected with mycoplasma from her birth canal during delivery. In conclusion, mycoplasma infections can be transmitted in various ways. Droplet transmission is the main infection of Mycoplasma pneumoniae, while external contact may infect a variety of mycoplasma, sexual transmission and mother-to-child transmission are mostly infected with human mycoplasma. Those who have contact with the source of infection should seek medical treatment promptly.