Irbesartan hydrochlorothiazide has no protein-lowering effect and belongs to the drugs that lower blood pressure. Irbesartan hydrochlorothiazide belongs to the compound preparation, the main clinical indications are hypertension, including Irbesartan and hydrochlorothiazide two ingredients, Irbesartan can inhibit angiotensin II receptor, by reducing the production of angiotensin vasodilatation to reduce blood pressure, hydrochlorothiazide through diuresis to lower blood pressure, the body’s protein does not have a lowering effect. Irbesartan hydrochlorothiazide can be used in the treatment of most hypertensive patients, especially for hypertension with edema, cardiac insufficiency patients, lowering blood pressure with diuretic effect. Irbesartan hydrochlorothiazide adverse reactions include dizziness, nausea, gastrointestinal discomfort, hypotension, fatigue, thirst, etc. Allergy to drug components, severe, liver and kidney insufficiency, lactation and pregnancy women are prohibited. Irbesartan hydrochlorothiazide should be used under the guidance of a physician to choose the right indications.