New Coronavirus vaccination can effectively prevent New Coronavirus infection, reduce the incidence of severe and critical illnesses, and reduce hospitalization and morbidity and mortality rates, but it is not suitable for everyone. According to the latest New Crown vaccination guidelines, vaccination is not recommended for the following groups of people: 1) those who are allergic to the vaccine or its components, or those who have previously received similar vaccines and developed severe allergies, such as acute allergic reactions, angioneurotic edema, and respiratory distress; 2) those with uncontrolled epilepsy and other severe neurological diseases, such as acute myelitis, Grimm- Barre syndrome, and demyelinating diseases; 3, people with immunodeficiency or immune disorders, such as nephrotic syndrome, chronic sarcoidosis, and allergic purpura; 4, people with fever, infection, or acute disease or acute onset of chronic disease, and patients with uncontrolled serious chronic diseases, such as acute pancreatitis, acute appendicitis, myocardial infarction, acute onset of hypertension, acute onset of diabetes 5. women who are pregnant or breastfeeding; 6. people who have received other vaccines within 14 days are also not recommended to receive New Crown vaccine. In view of the effectiveness and safety of vaccination, the above groups of people are not recommended to be vaccinated. Daily protection, such as wearing a mask and maintaining good personal hygiene, can also be effective in preventing Neoplasmosis infection. Some people, such as those with chronic illnesses that are well controlled by medication, or those whose symptoms of infection or fever have disappeared after the treatment of acute illnesses, may be vaccinated with the New Crown vaccine after consulting a doctor.