Infectious mononucleosis is an acute infectious disease caused by the EBV virus, which is common in pediatrics. The disease is characterized clinically by fever, pharyngitis, enlarged lymph nodes and liver and spleen, and a large number of abnormal lymphocytes in the peripheral blood. Based on the epidemic season and the characteristics of the disease, it is considered to be a febrile disease in the category of “plague” or “plague poison” or “phlegm poison”. Its treatment should be based on the basic principle of clearing heat and detoxifying toxins, and combining with clinical practice, the prescriptions and medicines should be applied flexibly to achieve certain curative effects.