I. Diagnosis based on: 1. Clinical symptoms, at least 3 positive.
(1) Fever.
(2) Pharyngitis, tonsillitis.
(3) Enlarged lymph nodes in the neck (25px or more).
(4) Enlarged liver (under 4 years old: more than 50px; over 4 years old: palpable).
(5) Enlarged spleen (palpable).
(6) Skin rash.
2. Blood tests.
(1) Leukocyte classification lymphocytes above 50% or total lymphocyte count above 5,0×109/L above 5 years old.
(2) Anomalous lymphocytes of 10% or more or total number higher than 1,0×109/L.
(3) Positive EBV antibody or EBV DNA test.
Second, the choice of treatment plan according to Practical Pediatrics (Hu Yami, Jiang Zai Fang, eds., People’s Health Press, 2002, 7th edition), Krugman’s Infectious Disease of Children (Anne A, Gershon, Peter J, Hotez. Samuel L, Katz, eds, Mosby Publishing, 2004, 11th edition).
1.General treatment: bed rest and intensive care to avoid serious complications.
2.Anti-viral treatment: prefer ganciclovir 5-10mg/Kg/d, intravenous infusion, once daily, for 7-10 days, or acyclovir at a dose of 5mg/Kg/d, intravenous infusion, three times daily, for 7-10 days.
3. Symptomatic treatment: antipyretic and analgesic measures, cough relief, liver protection, etc.
III. Standard hospitalization days are within 14 days.
IV. Clear diagnosis and routine examination for hospital admission.
1. Routine examination (1) routine blood, blood smear, routine urine, routine stool + occult blood; (2) liver and kidney function, at least one of EBVCIgM, EBVCIgG, EBVCDNA; (3) abdominal ultrasound (liver and spleen, kidney, abdominal lymph nodes).
2.Cellular immune function examination.
3.Bone marrow morphology examination.
V. Discharge criteria normal body temperature lasting more than 2 days, abnormal blood count lymphocytes <10%, and basic normal liver function (liver enzymes below 2 times the normal value).