The possible causes of finger swelling and pain after sleeping include rheumatoid arthritis, gout, onychomycosis, etc. Its treatment mainly includes general treatment, medication, physical therapy and surgery. 1. Rheumatoid arthritis flare-ups: non-steroidal anti-inflammatory drugs can be used, such as ibuprofen, indomethacin, loxoprofen, celecoxib, etc., which can alleviate the symptoms of swollen and painful fingers during the acute active phase. Methotrexate, salazosulfapyridine, azathioprine, and cyclophosphamide may also be used. Physical therapy such as magnetic therapy, ultrashort wave, and infrared light may also be used. In severe cases, surgery may be needed. 2. Gout: Colchicine, non-steroidal anti-inflammatory drugs, such as indomethacin, diclofenac, etc., and glucocorticoids can be used for treatment if necessary. As well as commonly used uric acid-lowering drugs, such as allopurinol, benzbromarone, probenecid, and so on. In severe cases, surgical treatment may be required. 3. Nail groove inflammation: when the symptoms are mild, you can soak your hands in warm water for 20 minutes a day, keep your hands clean and dry, and avoid prolonged immersion in water or prolonged contact with irritating detergents and chemical preparations. In acute attacks, local topical ichthyol ointment, fusidic acid cream, mupirocin ointment, etc. can be used. If there is abscess formation, surgical incision and drainage is required. The above drugs should be used under the guidance of a doctor or pharmacist. If you wake up with swollen and painful fingers, it is recommended that you seek medical attention to determine the cause of the problem and receive appropriate treatment.