Erythromycin ointment should not be used on pregnant women with itchy pubic area as its therapeutic effect on itchy pubic area is uncertain, while its use during pregnancy may be harmful. Erythromycin ointment has a safety rating of B for use in pregnancy, and there is a lack of data to support whether it is safe or not, so it is not recommended for self-administration if not necessary. Erythromycin ointment, as a topical preparation of macrolide antibiotics, is commonly used for localized skin infections, and can also be used for the treatment of some bacterial infectious diseases in gynecology. However, there are many causes of vaginal itching, such as eczema, local impurity, mycosis vaginalis, etc. Erythromycin ointment only has a therapeutic effect on vaginal itching caused by some bacterial infections. Therefore, if a pregnant woman’s pubic itching, she should consult a doctor in time and should not use erythromycin ointment externally by herself.