The side effects of saffron for men mainly include the occurrence of vomiting, bloating, diarrhea and loss of appetite. Saffron is cold in nature and has the efficacy of activating blood circulation to dispel blood stasis, cooling blood and removing toxins (referring to the treatment of blood-heat and toxin embodied in the blood), relieving depression and tranquilizing the mind, which can treat a series of symptoms caused by stasis of blood and stagnation of blood, such as women’s dysmenorrhea, amenorrhea, and so on. Men taking saffron for a long time will damage the yang qi of the spleen and stomach. Chinese medicine believes that the stomach is smooth by sinking and descending, after the spleen and stomach yang qi is damaged, the stomach qi rises instead of descending, vomiting will occur, the spleen qi rises instead of descending, diarrhea may occur, and the mild symptoms will be abdominal distension and loss of appetite. Patients taking saffron for a long period of time need to be closely observed, if there is a tendency to bleed it should not be used, in addition it is best not to eat cold drinks during the medication. It is important to take saffron correctly under the premise of TCM evidence-based treatment to avoid adverse reactions.