The treatment of perimenopausal syndrome includes: 1. psychotherapy, mainly refers to encourage patients and knowledge propaganda, should be faced with optimism; 2. maintain a reasonable diet structure, appropriate exercise, to ensure regular work and rest time; 3. diet needs to increase the intake of high protein or calcium-rich food to prevent osteoporosis; 4. appropriate sedative drugs or over-the-counter drugs such as glutathione to improve autonomic symptoms such as vertigo, palpitations, headache; 5. drug therapy, using hormone replacement therapy, strictly grasp the indications and contraindications.