The liver contains about 1/3 of the body’s iron stores and is the largest iron storage organ in the body, but excessive iron deposition in the liver can induce the formation of oxygen radicals, reactive oxygen species, and hydroxyl radicals in hepatocytes as a result of the Feton reaction, which can cause liver cell damage. The study showed that changes in ferritin levels are closely related to hepatocyte damage and the degree of damage; and that measuring ferritin levels can help in the diagnosis and treatment of liver disease.
Iron deficiency or overload is associated with many diseases, and ferritin levels can be used as a reference for the diagnosis and treatment of many diseases, from iron deficiency anemia when ferritin levels are decreased to tumors, liver disease, inflammatory reactions, or repeated blood transfusions when levels are increased.
Fein is the major storage protein for iron in the body and plays an important role in iron storage metabolism and homeostasis by preventing the toxic effects of high intracellular free Fe3+ levels through iron uptake and storage. The serum ferritin level is the main indicator of iron storage in the body. Ferritin is widely present in liver tissue and excessive iron deposition in the liver can cause liver cell damage.