Pleural irritation signs are known as pleural reactions. When pleurodesis is performed, some patients will have pleural reaction. Pleural reaction includes frequent irritating dry cough, dyspnea, shortness of breath, pallor, and in severe cases, shock and other symptoms. Once the pleural reaction occurs, the thoracentesis should be stopped immediately, the patient should be put in a flat position, and then dexamethasone 10mg intramuscular injection should be given, and the patient’s pleural reaction can usually be relieved. In addition, it is important to communicate well with the patient before puncture that pleural reaction may occur during puncture, so that the patient can be psychologically prepared.