Dry and hard stools, poor bowel movements, and changes in the normal frequency of bowel movements are called constipation. In medicine, constipation is usually divided into three types: slow transmission type, outlet obstruction type, and mixed type. The causes are broadly divided into the following: (1) eating less or too fine; (2) mental factors or life pattern changes resulting in interference with bowel habits; (3) drug abuse, such as morphine, opioids, etc., resulting in intestinal peristalsis suppression; (4) certain systemic diseases resulting in physical weakness, such as hypothyroidism, diabetes-induced peripheral neuropathy, etc.; (5) certain intestinal diseases, such as colitis, proctitis, etc. Proctitis, etc. At present, the clinical application of drugs for the treatment of constipation according to its principle can be divided into: volumetric laxatives, stimulant laxatives, lubricating laxatives, osmotic slow laxatives, intestinal dynamics drugs, as follows. 1, volumetric laxatives drugs are not absorbed by the intestine and dissolved in water, can absorb a lot of water in the intestine, so that the stool volume increases, intestinal peristalsis accelerated, play a diarrhea, such as magnesium sulfate. Such drugs are used in patients with alternating diarrhea and constipation or frail constipation, but it cannot increase colonic tone and should not be used for slow transmission type patients. Such as cellulose, polyethylene glycol, etc. 2, stimulating laxatives Such drugs are fruit guide, Bisacodyl, rhubarb, castor oil, senna, etc.. The drug itself or its metabolites stimulate the intestinal tract to increase peristalsis, fast action, strong effectiveness. These drugs are not suitable for long-term application because they can stimulate the intestinal mucosa and nerve plexus of the intestinal wall, and can cause weakness of the large intestinal muscles and form drug dependence. Drugs containing rhubarb, including detoxification capsules, can cause black lesions in the colon and increase the incidence of tumors. 3, lubricating laxatives Such drugs are also known as stool softeners, such as open cork, liquid paraffin, etc.. They can lubricate the intestinal wall and soften the stool, mainly used for the elderly or frail and sickly patients. But liquid paraffin wax long-term oral use, can cause malabsorption of fat-soluble vitamins. 4, osmotic laxatives such drugs are not absorbed by the body after taking, through the bacterial decomposition of organic acids released, improve the osmotic pressure in the colon, prevent water absorption, so that the intestinal volume increased, stimulating the intestinal wall caused by increased peristalsis and defecation. If sugar, Tongtai capsules, etc.. They are especially suitable for the elderly, maternity, children and post-surgical constipation. 5, intestinal motility drugs such as cisapride, by strengthening intestinal muscle tone to promote the role of small intestine and large intestine transit. For the long-term treatment of chronic constipation, but often need to be used in combination with other drugs. In addition, the 5-HT 4 agonist tegaserod has been shown to be effective in the constipated form of irritable bowel syndrome, especially in patients in whom osmotic laxatives and enteral fibrates have failed. To sum up, to completely treat constipation, not only should we distinguish the type of constipation, comprehensively analyze the etiology, reasonably choose the therapeutic drugs, but also start from the lifestyle, develop good habits, regular bowel movements, moderate exercise, eat more food rich in plant fiber, adjust the psychological state, supplemented by psychotherapy, which can gradually restore physiological bowel movements.