The low number of large platelets indicates that there are relatively more mature platelets in the blood, which may be due to pseudo-thrombocytopenia, insufficient platelet production, excessive platelet destruction, etc. It needs to be considered together with other indicators of blood routine 1. Pseudo-thrombocytopenia: the number of large platelets may be falsely lowered due to errors in the examination process. For example, when EDTA anticoagulant is used to draw blood, platelets will gather and clump together, resulting in errors in counting, and then the anticoagulant should be replaced with sodium citrate or heparin and then checked again. 2. Insufficient platelet production: such as after taking drugs to inhibit bone marrow function, anaplastic thrombocytopenia, aplastic anemia, etc., the number of large platelets may be low. It is recommended that the patient should consult the doctor in time to improve the relevant examination programs, such as bone marrow aspiration. Meanwhile, treatment should be carried out under the guidance of doctors. 3. Excessive platelet destruction: such as thrombocytopenic purpura, disseminated intravascular coagulation and other diseases, or the use of drugs that can lead to thrombocytopenia, such as antitumor drugs, immune-regulating drugs, etc., may lead to low platelet count. When low platelet count occurs, it is necessary to consult a doctor in time to clarify the cause of the disease and carry out treatment under the guidance of the doctor.